Anti-BANF1 Antibody

About this product

Boster Bio Anti-BANF1 Antibody (Catalog # A02734) . Tested in ELISA, WB, IF applications. This antibody reacts with Human.

Specifications

Catalog number

A02734

Size / count

0.1 mg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Barrier-to-autointegration factor 1 (BANF1) is a conserved chromatin protein that non-specifically binds double-stranded DNA. BANF1 also interacts with a family of nuclear proteins that include LAP2, emerin, and MAN1. It is also a host cell component of retroviral pre-integration complexes (PICs), including that of HIV. BANF1 will bind to p55 Gag (the structural precursor of HIV-1 virions) as well as its cleaved product matrix. In addition to being a host cell component of the PIC, it is thought that BANF1 is also present at low levels in incoming virions, and thus might contribute to the assembly or activity of HIV-1 PICs through direct binding to matrix as well as DNA.

Synonyms

BAF, NGPS, BCRP1, D14S1460, BAF, BCRG1, Barrier-to-autointegration factor, Breakpoint cluster region protein 1

Gene Name

BANF1

UniProt

O75531

Host

Rabbit

Reactivity

Human

Immunogen

Anti-BANF1 antibody was raised against a peptide corresponding to 15 amino acids near the carboxy terminus of human BANF1. The immunogen is located within the last 50 amino acids of BANF1.

Clonality

Polyclonal

Tissue Specificity

Widely expressed. Expressed in colon, brain, heart, kidney, liver, lung, ovary, pancreas, placenta, prostate, skeletal muscle, small intestine, spleen and testis. Not detected in thymus and peripheral blood leukocytes.

Applications

ELISA, WB, IF

Field of Research

Infectious Diseases

Purification

BANF1 Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Plays fundamental roles in nuclear assembly, chromatin organization, gene expression and gonad development. May potently compress chromatin structure and be involved in membrane recruitment and chromatin decondensation during nuclear assembly. Contains 2 non-specific dsDNA-binding sites which may promote DNA cross-bridging.

Storage Conditions

BANF1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Observed Molecular Weight

10059 MW

Gene Name Synonym

Barrier to autointegration factor 1

Subcellular Location

Barrier-to-autointegration factor: Nucleus

Prediction Reactivity

Mouse, Rat

Protein Name

Barrier to autointegration factor 1

Isotype

IgG

Contents

BANF1 Antibody is supplied in PBS containing 0.02% sodium azide.