Anti-Granzyme A GZMA Antibody

About this product

Boster Bio Anti-Granzyme A GZMA Antibody catalog # A02779. Tested in WB, IF applications. This antibody reacts with Human, Mouse, Rat.

Specifications

Catalog number

A02779

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

Granzyme A;3.4.21.78; CTL tryptase; Cytotoxic T-lymphocyte proteinase 1; Fragmentin-1; Granzyme-1; Hanukkah factor; H factor; HF; GZMA; CTLA3, HFSP

Gene Name

GZMA

UniProt

P12544

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant full length Human GZMA.

Clonality

Polyclonal

Applications

WB, IF

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Concentration

1 mg/mL

Form

Liquid

Function

Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent cell death with morphological features of apoptosis when delivered into the target cell through the immunological synapse. It cleaves after Lys or Arg. Cleaves APEX1 after 'Lys-31' and destroys its oxidative repair activity. Cleaves the nucleosome assembly protein SET after 'Lys-189', which disrupts its nucleosome assembly activity and allows the SET complex to translocate into the nucleus to nick and degrade the DNA.

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

28999 MW

Gene Name Synonym

Granzyme A

Subcellular Location

Isoform alpha: Secreted. Cytoplasmic granule.

Protein Name

Granzyme A

Contents

Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2