Anti-JMJD2A KDM4A Antibody

About this product

Boster Bio Anti-JMJD2A KDM4A Antibody (Catalog # A02850) . Tested in ELISA, WB, IHC-P applications. This antibody reacts with Human, Mouse, Rat.

Specifications

Catalog number

A02850

Size / count

0.1 mg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Members of the Jumonji domain 2 (JMJD2) family contain a JmjN domain, a JmjC domain, a JD2H domain, two TUDOR domains, and two PHD-type zinc fingers. The first member of this group, JMJD2A, is widely expressed in human tissues and cell lines and functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form, and as a transcriptional repressor. JMJD2A can also form a complex with the androgen receptor (AR), a transcription factor that is pivotal for the development of prostate cancer. Overexpression of JMJD2A stimulates AR function and this stimulation is dependent on JMJD2A catalytic activity, suggesting that JMJD2A might be a critical protein with roles in cell proliferation and oncogenesis.

Synonyms

JMJD2, JHDM3A, JMJD2A, TDRD14A, JMJD2, KIAA0677, Lysine-specific demethylase 4A, JmjC domain-containing histone demethylation protein 3A

Gene Name

KDM4A

UniProt

O75164

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

JMJD2A antibody was raised against a 14 amino acid synthetic peptide from near the center of human JMJD2A. The immunogen is located within amino acids 340 - 390 of JMJD2A.

Clonality

Polyclonal

Tissue Specificity

Ubiquitous.

Applications

ELISA, WB, IHC-P

Field of Research

Cancer

Purification

JMJD2A Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Histone demethylase that specifically demethylates 'Lys- 9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code (PubMed:26741168) . Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively.

Storage Conditions

JMJD2A antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Observed Molecular Weight

120662 MW

Gene Name Synonym

Lysine (K) -specific demethylase 4A

Subcellular Location

Nucleus

Protein Name

Lysine (K) -specific demethylase 4A

Isotype

IgG

Contents

JMJD2A Antibody is supplied in PBS containing 0.02% sodium azide.