Anti-R-Spondin RSPO1 Monoclonal Antibody

About this product

Boster Bio Anti-R-Spondin RSPO1 Monoclonal Antibody catalog # A02857. Tested in WB, ELISA applications. This antibody reacts with Human.

Specifications

Catalog number

A02857

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

R-spondin-1; Roof plate-specific spondin-1; hRspo1; RSPO1

Gene Name

RSPO1

UniProt

Q2MKA7

Host

Mouse

Reactivity

Human

Immunogen

Purified recombinant fragment of R-spondin1 expressed in E. Coli.

Clonality

Monoclonal

Clone

Clone: 7A6

Tissue Specificity

Abundantly expressed in adrenal glands, ovary, testis, thyroid and trachea but not in bone marrow, spinal cord, stomach, leukocytes colon, small intestine, prostate, thymus and spleen. .

Applications

WB, ELISA

Purification

Affinity purification

Concentration

1 mg/mL

Form

Liquid

Function

Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination. .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

28959 MW

Gene Name Synonym

R-spondin-1

Subcellular Location

Secreted . Nucleus . Seems to mainly localize to nucleoli. .

Isotype

IgG1

Contents

Ascitic fluid containing 0.03% sodium azide.

Conjugate

Unconjugated