Anti-60S ribosomal protein L11 RPL11 Antibody

About this product

Boster Bio Anti-60S ribosomal protein L11 RPL11 Antibody catalog # A02901. Tested in WB, ICC applications. This antibody reacts with Human, Mouse, Rat.

Specifications

Catalog number

A02901

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

60S ribosomal protein L11; CLL-associated antigen KW-12; Large ribosomal subunit protein uL5

Gene Name

RPL11

UniProt

P62913

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide, corresponding to amino acids 133-178 of Human RPL11.

Clonality

Polyclonal

Applications

WB, ICC

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Concentration

1 mg/mL

Form

Liquid

Function

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl- transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. As part of the 5S RNP/5S ribonucleoprotein particle it is an essential component of the LSU, required for its formation and the maturation of rRNAs (PubMed:19061985, PubMed:12962325, PubMed:24120868) . It also couples ribosome biogenesis to p53/TP53 activation. As part of the 5S RNP it accumulates in the nucleoplasm and inhibits MDM2, when ribosome biogenesis is perturbed, mediating the stabilization and the activation of TP53 (PubMed:24120868) . Promotes nucleolar location of PML (By similarity) .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

20252 MW

Gene Name Synonym

60S ribosomal protein L11

Subcellular Location

Nucleus, nucleolus

Protein Name

60S ribosomal protein L11

Contents

Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2