Anti-Aprataxin APTX Antibody

About this product

Boster Bio Anti-Aprataxin APTX Antibody catalog # A02968. Tested in WB, ICC/IF, IP applications. This antibody reacts with Human.

Specifications

Catalog number

A02968

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

Aprataxin;3.1.11.7

Gene Name

APTX

UniProt

Q7Z2E3

Host

Rabbit

Reactivity

Human

Immunogen

Recombinant fusion protein of human APTX (NP_001182178.1) .

Clonality

Polyclonal

Tissue Specificity

Widely expressed; detected in liver, kidney and lymph node (at protein level) (PubMed:14755728) . Isoform 1 is highly expressed in the cerebral cortex and cerebellum, compared to isoform 2 (at protein level) (PubMed:14755728) . Widely expressed; detected throughout the brain, in liver, kidney, skeletal muscle, fibroblasts, lymphocytes and pancreas (PubMed:15276230, PubMed:11586299, PubMed:11586300) .

Applications

WB, ICC, IF, IP

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Concentration

1 mg/mL

Form

Liquid

Function

DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair (PubMed:15380105, PubMed:15044383, PubMed:16964241, PubMed:17276982, PubMed:24362567) . Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species (PubMed:16964241, PubMed:24362567) . Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined (PubMed:16964241, PubMed:17276982, PubMed:24362567) . Also able to hydrolyze adenosine 5'- monophosphoramidate (AMP-NH (2) ) and diadenosine tetraphosphate (AppppA), but with lower catalytic activity (PubMed:16547001) . Likewise, catalyzes the release of 3'-linked guanosine (DNAppG) and inosine (DNAppI) from DNA, but has higher specific activity with 5'-linked adenosine (AppDNA) (By similarity) .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

40740 MW

Gene Name Synonym

Aprataxin

Subcellular Location

Nucleus, nucleoplasm

Protein Name

Aprataxin

Contents

Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2