Anti-PREX1 Antibody (C-term)

About this product

Boster Bio Anti-PREX1 Antibody (C-term) (Catalog # A03098-1) . Tested in IHC-P, WB, Flow Cytometry application (s) . This antibody reacts with Human.

Specifications

Catalog number

A03098-1-80ul

Size / count

80 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

The protein encoded by this gene acts as a guanine nucleotide exchange factor for the RHO family of small GTP-binding proteins (RACs) . It has been shown to bind to and activate RAC1 by exchanging bound GDP for free GTP. The encoded protein, which is found mainly in the cytoplasm, is activated by phosphatidylinositol-3,4,5-trisphosphate and the beta-gamma subunits of heterotrimeric G proteins.

Synonyms

Phosphatidylinositol 3,5-trisphosphate-dependent Rac exchanger 1 protein, P-Rex1, PtdIns (3,5) -dependent Rac exchanger 1, PREX1, KIAA1415

Gene Name

PREX1

UniProt

Q8TCU6

Host

Rabbit

Reactivity

Human

Immunogen

This PREX1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1134-1163 amino acids from the C-terminal region of human PREX1.

Clonality

Polyclonal

Tissue Specificity

Mainly expressed in peripheral blood leukocytes and brain. Expressed at intermediate level in spleen and lymph nodes, and weakly expressed in other tissues

Applications

IHC-P, WB, Flow Cytometry

Field of Research

Cell Biology, Signal Transduction, Chemokine signaling, Inflammation

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Function

Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils.

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Observed Molecular Weight

186203 Da

Subcellular Location

Cytoplasm, cytosol. Cell membrane. Note=Mainly cytosolic. Some amount is apparently associated to the plasma membrane

Isotype

Rabbit IgG

Contents

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.