Anti-CDK5RAP2 Antibody

About this product

Boster Bio Anti-CDK5RAP2 Antibody (Catalog# A03102) . Tested in IHC, ICC, IF, ELISA applications. This antibody reacts with Human, Mouse, Rat.

Specifications

Catalog number

A03102

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

CDK5RAP2; CEP215; KIAA1633; CDK5 regulatory subunit-associated protein 2; CDK5 activator-binding protein C48; Centrosome-associated protein 215

Gene Name

CDK5RAP2

UniProt

Q96SN8

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

A peptide derived from human CDK5RAP2. Immunogen sequence location: 251-300

Clonality

Polyclonal

Tissue Specificity

Widely expressed. Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

Applications

IHC, ICC, IF, ELISA

Field of Research

Cell Biology, Cell Cycle, Chromosome Structure, Cytoskeleton, Cytoskeleton/ECM, Epigenetics and Nuclear Signaling, Kinases/Phosphatases, Microtubules, Neurogenesis, Neurology Process, Neuroscience, Organelles, Signal Transduction, Subcellular Markers, Tags & Cell Markers, Tubulin

Purification

The antibody was purified from rabbit antiserum by affinity-chromatography using immunogen.

Concentration

0.5-1mg/mL, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Form

Liquid

Function

Potential regulator of CDK5 activity via its interaction with CDK5R1. Negative regulator of centriole disengagement (licensing) which maintains centriole engagement and cohesion. Involved in regulation of mitotic spindle orientation (By similarity) . Plays a role in the spindle checkpoint activation by acting as a transcriptional regulator of both BUBR1 and MAD2 promoter. Together with MAPRE1, it may promote microtubule polymerization, bundle formation, growth and dynamics at the plus ends. Regulates centrosomal maturation by recruitment of a gamma- tubulin ring complex onto centrosomes (PubMed:26485573) .

Storage Conditions

Store at -20°C for one year. For short-term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

215038 MW

Gene Name Synonym

CDK5 regulatory subunit-associated protein 2

Subcellular Location

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Golgi apparatus.Cytoplasm. Found in the pericentriolar region adhering to the surface of the centrosome and in the region of the centrosomal appendages. Localizes to microtubule plus ends.

Isotype

Rabbit IgG

Contents

PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.