Anti-ENPP2 Antibody (Center)

About this product

Boster Bio Anti-ENPP2 Antibody (Center) (Catalog # A03110-1) . Tested in WB, Flow Cytometry application (s) . This antibody reacts with Human.

Specifications

Catalog number

A03110-1-200ul

Size / count

200 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

ENPP2 functions as both a phosphodiesterase, which cleaves phosphodiester bonds at the 5' end of oligonucleotides, and a phospholipase, which catalyzes production of lysophosphatidic acid (LPA) in extracellular fluids. LPA evokes growth factor-like responses including stimulation of cell proliferation and chemotaxis. This protein stimulates the motility of tumor cells and has angiogenic properties, and its expression is upregulated in several kinds of carcinomas. The protein is secreted and further processed to make the biologically active form.

Synonyms

Ectonucleotide pyrophosphatase/phosphodiesterase family member 2, E-NPP 2, Autotaxin, Extracellular lysophospholipase D, LysoPLD, ENPP2, ATX, PDNP2

Gene Name

ENPP2

UniProt

Q13822

Host

Rabbit

Reactivity

Human

Immunogen

This ENPP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 377-406 amino acids from the Central region of human ENPP2.

Clonality

Polyclonal

Tissue Specificity

Detected in blood plasma (at protein level) (PubMed:12176993, PubMed:26371182) . Predominantly expressed in brain, placenta, ovary, and small intestine. Expressed in a number of carcinomas such as hepatocellular and prostate carcinoma, neuroblastoma and non-small-cell lung cancer. Expressed in body fluids such as plasma, cerebral spinal fluid (CSF), saliva, follicular and amniotic fluids. Not detected in leukocytes. Isoform 1 is more highly expressed in peripheral tissues than in the central nervous system (CNS) Adipocytes only express isoform 1. Isoform 3 is more highly expressed in the brain than in peripheral tissues.

Applications

WB, Flow Cytometry

Field of Research

Cancer, Cardiovascular, Metabolism, Neuroscience, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Function

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Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Observed Molecular Weight

98994 Da

Subcellular Location

Secreted

Isotype

Rabbit IgG

Contents

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.