Anti-SRSF3 Antibody

About this product

Boster Bio Anti-SRSF3 Antibody (Catalog # A03127) . Tested in ELISA, WB, ICC, IF applications. This antibody reacts with Human, Mouse, Rat.

Specifications

Catalog number

A03127

Size / count

0.1 mg

Dry ice

No

Hazardous

No

Discontinued

No

Background

SRSF3, a member of the serine/arginine (SR) -rich family of pre-mRNA splicing factors which constitute part of the spliceosome, may be involved in RNA processing in relation with cellular proliferation and/or maturation (1,2) . Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins (3) . The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation (3,4) .

Synonyms

Serine/arginine-rich splicing factor 3, Pre-mRNA-splicing factor SRP20, SFRS3, Splicing factor arginine/serine-rich 3, SRP20

Gene Name

SRSF3

UniProt

P84103

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

SRSF3 antibody is human, mouse and rat reactive.

Immunogen

SRSF3 antibody was raised against a 19 amino acid peptide near the center of human SRSF3. The immunogen is located within amino acids 80 - 130 of SRSF3.

Clonality

Polyclonal

Applications

ELISA, WB, ICC, IF

Field of Research

Homeostasis, Cancer

Purification

SRSF3 antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Splicing factor that specifically promotes exon- inclusion during alternative splicing (PubMed:26876937) . Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A) -containing RNAs, promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing (PubMed:26876937) . Also functions as export adapter involved in mRNA nuclear export (PubMed:11336712, PubMed:18364396, PubMed:28984244) . Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway) ; enhances NXF1-NXT1 RNA-binding activity (PubMed:11336712, PubMed:18364396) . Involved in nuclear export of m6A-containing mRNAs via interaction with YTHDC1: interaction with YTHDC1 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export (PubMed:28984244) . RNA-binding is semi-sequence specific (PubMed:17036044) .

Storage Conditions

SRSF3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Observed Molecular Weight

19330 MW

Gene Name Synonym

Serine/arginine-rich splicing factor 3

Subcellular Location

Nucleus

Prediction Reactivity

Bovine

Protein Name

Serine/arginine-rich splicing factor 3

Isotype

IgG

Contents

SRSF3 antibody is supplied in PBS containing 0.02% sodium azide.