Anti-ABCA7 Antibody

About this product

Boster Bio Anti-ABCA7 Antibody (Catalog # A03163) . Tested in ELISA, WB, IHC-P, ICC, IF applications. This antibody reacts with Human.

Specifications

Catalog number

A03163

Size / count

0.1 mg

Dry ice

No

Hazardous

No

Discontinued

No

Background

ATP-binding cassette (ABC) transporters are an evolutionarily conserved family that use ATP hydrolysis to catalyze the transport of various molecules across cell membranes. They are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White) . ABCA7, a member of the ABC1 subfamily, is a full-size ABC transporter consisting of two sets of the multiple membrane-spanning domains plus the Walker motifs for the ATP interaction. ABCA7 shows the highest homology to ABCA1, an essential molecule for cholesterol homeostasis. The high expression levels of ABCA7 in peripheral leukocytes, thymus, spleen and bone marrow suggests a role in the immune system lipid homeostasis.

Synonyms

ABCX, ABCA-SSN, ATP-binding cassette sub-family A member 7

Gene Name

ABCA7

UniProt

Q8IZY2

Host

Rabbit

Reactivity

Human

Cross Reactivity

ABCA7 antibody is predicted to not cross-react with other ABC1 subfamily proteins.

Immunogen

ABCA7 antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human ABCA7. The immunogen is located within amino acids 130 - 180 of ABCA7.

Clonality

Polyclonal

Tissue Specificity

Expressed in leukocytes (at protein level) . Widely expressed. Highly expressed in myelo-lymphatic tissues including peripheral leukocytes, thymus, spleen and bone marrow. Isoform 2 is more abundant in lymph node, spleen, thymus and trachea than isoform 1 which is more strongly expressed in brain and bone marrow.

Applications

ELISA, WB, IHC-P, ICC, IF

Field of Research

Homeostasis

Purification

ABCA7 Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Plays a role in phagocytosis by macrophages of apoptotic cells. Binds APOA1 and may function in apolipoprotein-mediated phospholipid efflux from cells. May also mediate cholesterol efflux. May regulate cellular ceramide homeostasis during keratinocytes differentiation.

Storage Conditions

ABCA7 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Observed Molecular Weight

234350 MW

Gene Name Synonym

ATP-binding cassette, sub-family A (ABC1), member 7

Subcellular Location

Cell membrane

Protein Name

ATP-binding cassette, sub-family A (ABC1), member 7

Isotype

IgG

Contents

ABCA7 Antibody is supplied in PBS containing 0.02% sodium azide.