Anti-Forkhead box protein N1 FOXN1 Antibody

About this product

Boster Bio Anti-Forkhead box protein N1 FOXN1 Antibody catalog # A03369. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.

Specifications

Catalog number

A03369

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

Forkhead box protein N1; Winged-helix transcription factor nude; FOXN1; RONU, WHN

Gene Name

FOXN1

UniProt

O15353

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

A synthetic peptide corresponding to residues in Human FOXN1.

Clonality

Polyclonal

Tissue Specificity

Expressed in thymus.

Applications

WB

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Concentration

1 mg/mL

Form

Liquid

Function

Transcriptional regulator which regulates the development, differentiation, and function of thymic epithelial cells (TECs) both in the prenatal and postnatal thymus. Acts as a master regulator of the TECs lineage development and is required from the onset of differentiation in progenitor TECs in the developing fetus to the final differentiation steps through which TECs mature to acquire their full functionality. Regulates, either directly or indirectly the expression of a variety of genes that mediate diverse aspects of thymus development and function, including MHC Class II, DLL4, CCL25, CTSL, CD40 and PAX1. Regulates the differentiation of the immature TECs into functional cortical TECs (cTECs) and medullary TECs (mTECs) . Essential for maintenance of mTECs population in the postnatal thymus. Involved in the morphogenesis and maintenance of the three-dimensional thymic microstructure which is necessary for a fully functional thymus. Plays an important role in the maintenance of hematopoiesis and particularly T lineage progenitors within the bone marrow niche with age. Essential for the vascularization of the thymus anlage. Promotes the terminal differentiation of epithelial cells in the epidermis and hair follicles, partly by negatively regulating the activity of protein kinase C (By similarity) . Plays a crucial role in the early prenatal stages of T-cell ontogeny (PubMed:21507891) .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

68925 MW

Applications Notes

WB: 1:500-1:1000

Gene Name Synonym

Forkhead box protein N1

Subcellular Location

Nucleus.

Protein Name

Forkhead box protein N1

Contents

Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2