Anti-Kallikrein-4 KLK4 Antibody

About this product

Boster Bio Anti-Kallikrein-4 KLK4 Antibody (Catalog # A03430) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human.

Specifications

Catalog number

A03430

Size / count

0.1 mg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Kallikreins (KLKs) belong to the serine protease family of proteolytic enzymes having diverse physiological functions (1) . Kallikrein 4 (KLK4), also known as prostase or EMSP1 (enamel matrix serine protease 1), contains one peptidase S1 domain and the expression in prostate is regulated by hormone (1,2) . Many kallikreins are implicated in carcinogenesis and have potential as novel cancer and other disease biomarkers (3) . KLK4 may have additional roles such as functioning as one of the two major enamel proteases identified that process enamel matrix proteins. Defects in KLK4 are the cause of amelogenesis imperfecta hypomaturation type 2A1 (AI2A1) (4) .

Synonyms

ARM1, EMSP, PSTS, AI2A1, EMSP1, KLK-L1, PRSS17, kallikrein, Kallikrein-4, Enamel matrix serine proteinase 1

Gene Name

KLK4

UniProt

Q9Y5K2

Host

Rabbit

Reactivity

Human

Cross Reactivity

KLK4 antibody is human specific. At least three isoforms of KLK4 are known to exist.

Immunogen

KLK4 antibody was raised against a 15 amino acid peptide near the center of human KLK4. The immunogen is located within amino acids 80 - 130 of KLK4 .

Clonality

Polyclonal

Tissue Specificity

Expressed in prostate.

Applications

ELISA, WB, IHC-P, IF

Field of Research

Cancer, Cell Cycle

Purification

KLK4 Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Has a major role in enamel formation (PubMed:15235027) . Required during the maturation stage of tooth development for clearance of enamel proteins and normal structural patterning of the crystalline matrix (By similarity) .

Storage Conditions

KLK4 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Observed Molecular Weight

27032 MW

Gene Name Synonym

Kallikrein-related peptidase 4

Subcellular Location

Secreted.

Protein Name

Kallikrein-related peptidase 4

Isotype

IgG

Contents

KLK4 Antibody is supplied in PBS containing 0.02% sodium azide.