Anti-RAGE AGER Antibody

Catalog number A03438

Price for A03438

Size / count 100 µL

About this product

Boster Bio Anti-RAGE AGER Antibody catalog # A03438. Tested in WB, ICC/IF, IHC, Flow Cytometry applications. This antibody reacts with Human, Mouse, Rat.

Specifications

Catalog number: A03438
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
Synonyms: Advanced glycosylation end product-specific receptor; Receptor for advanced glycosylation end products; AGER; RAGE
Gene Name: AGER
UniProt: Q15109
Host: Rabbit
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant protein
Clonality: Polyclonal
Tissue Specificity: Endothelial cells.
Applications: WB, ICC, IF, IHC, Flow Cytometry
Purification: ProA affinity purified
Concentration: 1 mg/mL
Form: Liquid
Function: Mediates interactions of advanced glycosylation end products (AGE) . These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF- alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity) . Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Can also bind oligonucleotides.
Storage Conditions: Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight: 42803 MW
Gene Name Synonym: Advanced glycosylation end product-specific receptor
Subcellular Location: Isoform 1: Cell membrane; Single-pass type I membrane protein.
Protein Name: Advanced glycosylation end product-specific receptor
Contents: Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Frequently Asked Questions

What is the catalog number for Anti-RAGE AGER Antibody?

The catalog number for Anti-RAGE AGER Antibody is A03438.

What sizes are available for Anti-RAGE AGER Antibody?

Anti-RAGE AGER Antibody is available in the following size(s): 100 µL.

Is Anti-RAGE AGER Antibody in stock?

Anti-RAGE AGER Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

Where can I find the safety data sheet (SDS/MSDS) for Anti-RAGE AGER Antibody?

The safety data sheet for Anti-RAGE AGER Antibody is available here: https://www.bosterbio.com/msds?sku=A03438.

What is Anti-RAGE AGER Antibody used for?

Boster Bio Anti-RAGE AGER Antibody catalog # A03438. Tested in WB, ICC/IF, IHC, Flow Cytometry applications. This antibody reacts with Human, Mouse, Rat.

Does this cell line or biologic require a Material Transfer Agreement (MTA)?

Some products, including certain cell lines, plasmids, and tissue cultures, are subject to intellectual property terms and may require an MTA before we can ship. We’ll inform you in advance if this product requires one, and additional handling fees may apply.

What should I do if I need to report a performance issue with a specific lot of this product?

Provide the catalogue number, product name, lot number, and your experimental results to our technical support team. They’ll investigate and, if needed, escalate to the manufacturer, provided the product was used before expiry and stored correctly.

What is the isotype of this antibody?

Isotype information such as IgG1 or IgG2a is listed in the product specifications on the datasheet, relevant for selecting compatible detection reagents.