Anti-CD305 LAIR1 Antibody

About this product

Boster Bio Anti-CD305 LAIR1 Antibody catalog # A03470. Tested in WB, ELISA applications. This antibody reacts with Human, Mouse, Rat.

Specifications

Catalog number

A03470

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

Leukocyte-associated immunoglobulin-like receptor 1; LAIR-1; hLAIR1; CD305; LAIR1; CD305

Gene Name

LAIR1

UniProt

Q6GTX8

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

The antiserum was produced against synthesized peptide derived from the Internal region of human LAIR1. AA range:21-70

Clonality

Polyclonal

Tissue Specificity

Expressed on the majority of peripheral mononuclear cells, including natural killer (NK) cells, T-cells, B-cells, monocytes, and dendritic cells. Highly expressed in naive T-cells and B-cells but no expression on germinal center B-cells. Abnormally low expression in naive B-cells from HIV-1 infected patients. Very low expression in NK cells from a patient with chronic active Epstein-Barr virus infection.

Applications

WB, ELISA

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/mL

Form

Liquid

Function

Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T-cells, down- regulating IL2 and IFNG production while inducing secretion of transforming growth factor beta. Down-regulates also IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells. Inhibits the differentiation of peripheral blood precursors towards dendritic cells.

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

31412 MW

Gene Name Synonym

Leukocyte-associated immunoglobulin-like receptor 1

Subcellular Location

Cell membrane

Protein Name

Leukocyte-associated immunoglobulin-like receptor 1

Isotype

IgG

Contents

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.