Anti-Protein Wnt-10a Wnt10a Antibody

About this product

Boster Bio Anti-Protein Wnt-10a Wnt10a Antibody (Catalog # A03479) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.

Specifications

Catalog number

A03479

Size / count

0.1 mg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Wnt10a is a member of the Wnt family, a gene family that encodes secreted signaling proteins that play crucial roles in normal development such as regulation of cell fate and patterning during embryogenesis as well as neoplastic transformation. Elevated levels of Wnt10a have been detected in several human tumors and cancer cell lines including colorectal cancer and chronic lymphocytic leukemia and it has been suggested that uncontrolled Wnt signaling may contribute to the defect in apoptosis that characterizes these malignancies. Recently, a mutation in Wnt10a was found to be associated with odonto-onycho-dermal dysplasia, an autosomal recessive ectodermal dysplasia.

Synonyms

OODD, SSPS, STHAG4, Protein Wnt-10a

Gene Name

WNT10A

UniProt

Q9GZT5

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

This Wnt10a antibody is predicted to not cross-react with Wnt10b.

Immunogen

Wnt10a antibody was raised against a 14 amino acid synthetic peptide from near the carboxy terminus of human Wnt10a. The immunogen is located within amino acids 300 - 350 of Wnt10a.

Clonality

Polyclonal

Tissue Specificity

High expression in adult brain, moderate expression in fetal brain, and weak expression in adult liver, kidney, and spinal cord and in select brain regions, including amygdala, corpus callosum, caudate nucleus, and hippocampus.

Applications

ELISA, WB, IHC-P, IF

Field of Research

Signal Transduction, Cancer

Purification

Wnt10a Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Ligand for members of the frizzled family of seven transmembrane receptors (Probable) . Functions in the canonical Wnt/beta-catenin signaling pathway (By similarity) . Plays a role in normal ectoderm development (PubMed:17847007, PubMed:28589954) . Required for normal tooth development (PubMed:17847007, PubMed:29178643, PubMed:28589954) . Required for normal postnatal development and maintenance of tongue papillae and sweat ducts (PubMed:28589954) . Required for normal proliferation of basal cells in tongue filiform papillae, plantar epithelium and sweat ducts. Required for normal expression of keratins in tongue papillae (By similarity) . Required for normal expression of KRT9 in foot plant epithelium (PubMed:28589954) . Required for normal hair follicle function (PubMed:28589954) .

Storage Conditions

Wnt10a antibody can be stored at 4°C up to one year. Antibodies should not be exposed to prolonged high temperatures.

Observed Molecular Weight

46444 MW

Gene Name Synonym

Wingless-type MMTV integration site family, member 10A

Subcellular Location

Secreted, extracellular space, extracellular matrix . Secreted

Protein Name

Wingless-type MMTV integration site family, member 10A

Isotype

IgG

Contents

Wnt10a Antibody is supplied in PBS containing 0.02% sodium azide.