Anti-Unconventional myosin-X MYO10 Antibody

About this product

Boster Bio Anti-Unconventional myosin-X MYO10 Antibody catalog # A03647. Tested in WB, ICC/IF applications. This antibody reacts with Human, Mouse.

Specifications

Catalog number

A03647

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

Unconventional myosin-X; Unconventional myosin-10; MYO10; KIAA0799

Gene Name

MYO10

UniProt

Q9HD67

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

Recombinant fusion protein of human MYO10 (NP_036466.2) .

Clonality

Polyclonal

Tissue Specificity

Ubiquitous.

Applications

WB, ICC, IF

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Concentration

1 mg/mL

Form

Liquid

Function

Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. MYO10 binds to actin filaments and actin bundles and functions as plus end-directed motor. The tail domain binds to membranous compartments containing phosphatidylinositol 3,4,5-trisphosphate or integrins, and mediates cargo transport along actin filaments. Regulates cell shape, cell spreading and cell adhesion. Stimulates the formation and elongation of filopodia. May play a role in neurite outgrowth and axon guidance. In hippocampal neurons it induces the formation of dendritic filopodia by trafficking the actin-remodeling protein VASP to the tips of filopodia, where it promotes actin elongation. Plays a role in formation of the podosome belt in osteoclasts.

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

237347 MW

Gene Name Synonym

Unconventional myosin-X

Subcellular Location

Cytoplasm, cytosol

Protein Name

Unconventional myosin-X

Contents

Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2