Anti-NDE1 Antibody

About this product

Boster Bio Anti-NDE1 Antibody catalog # A03656. Tested in WB, IF applications. This antibody reacts with Human, Mouse.

Specifications

Catalog number

A03656

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

Nuclear distribution protein nudE homolog 1; NudE; NDE1; NUDE

Gene Name

NDE1

UniProt

Q9NXR1

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

Recombinant full length Human NDE1.

Clonality

Polyclonal

Tissue Specificity

Expressed in the neuroepithelium throughout the developing brain, including the cerebral cortex and cerebellum.

Applications

WB, IF

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Concentration

1 mg/mL

Form

Liquid

Function

Required for centrosome duplication and formation and function of the mitotic spindle. Essential for the development of the cerebral cortex. May regulate the production of neurons by controlling the orientation of the mitotic spindle during division of cortical neuronal progenitors of the proliferative ventricular zone of the brain. Orientation of the division plane perpendicular to the layers of the cortex gives rise to two proliferative neuronal progenitors whereas parallel orientation of the division plane yields one proliferative neuronal progenitor and a post- mitotic neuron. A premature shift towards a neuronal fate within the progenitor population may result in an overall reduction in the final number of neurons and an increase in the number of neurons in the deeper layers of the cortex.

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

37721 MW

Gene Name Synonym

Nuclear distribution protein nudE homolog 1

Subcellular Location

Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Cleavage furrow. Localizes to the interphase and S phase centrosome. During mitosis, partially associated with the mitotic spindle. Concentrates at the plus ends of microtubules coincident with kinetochores in metaphase and anaphase in a CENPF- dependent manner. Also localizes to the cleavage furrow during cytokinesis. manner. Also localizes to the cleavage furrow during cytokinesis.

Protein Name

Nuclear distribution protein nudE homolog 1

Contents

Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2