Anti-CLAUDIN4 CLDN4 Antibody

About this product

Boster Bio Anti-CLAUDIN4 CLDN4 Antibody (Catalog # A03683) . Tested in ELISA, WB, IF applications. This antibody reacts with Human.

Specifications

Catalog number

A03683

Size / count

0.1 mg

Dry ice

No

Hazardous

No

Discontinued

No

Background

CLAUDIN4 is an integral membrane protein belonging to the claudin family, a family of cellular adhesion molecules that are components of tight junctions. CLAUDIN4 is a component of tight junction strands and may play a role in internal organ development and function during pre- and postnatal life. The CLAUDIN4 gene is deleted in Williams-Beuren syndrome, a neurodevelopmental disorder affecting multiple systems. CLAUDIN4 is frequently overexpressed in ovarian and other epithelial cancers.

Synonyms

CPER, CPE-R, CPETR, CPETR1, WBSCR8, hCPE-R, CPER, Claudin-4, Clostridium perfringens enterotoxin receptor

Gene Name

CLDN4

UniProt

O14493

Host

Rabbit

Reactivity

Human

Cross Reactivity

At least four isoforms of CLAUDIN4 are known to exist; CLAUDIN4 antibody will detect all four isoforms

Immunogen

Anti-CLAUDIN4 antibody was raised against a peptide corresponding to 17 amino acids near the carboxy terminus of human CLAUDIN4. The immunogen is located within the last 50 amino acids of CLAUDIN4.

Clonality

Polyclonal

Applications

ELISA, WB, IF

Field of Research

Cancer, Cell Cycle

Purification

CLAUDIN4 Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Channel-forming tight junction protein that mediates paracellular chloride transport in the kidney. Plays a critical role in the paracellular reabsorption of filtered chloride in the kidney collecting ducts. Claudins play a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.

Storage Conditions

CLAUDIN4 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Observed Molecular Weight

22077 MW

Gene Name Synonym

Claudin 4

Subcellular Location

Cell junction, tight junction

Prediction Reactivity

Bovine, Mouse, Rat

Protein Name

Claudin 4

Isotype

IgG

Contents

CLAUDIN4 Antibody is supplied in PBS containing 0.02% sodium azide.