Anti-APC3 CDC27 Antibody

About this product

Boster Bio Anti-APC3 CDC27 Antibody (Catalog # A03905) . Tested in ELISA, WB, IHC-P applications. This antibody reacts with Human, Mouse, Rat.

Specifications

Catalog number

A03905

Size / count

0.1 mg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Cell cycle regulated protein ubiquitination and degradation within subcellular domains is thought to be essential for the normal progression of mitosis. APC3, also known as CDC27, a highly conserved component of the anaphase promoting complex/cyclosome (APC/C), is a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. APC/C is responsible for degrading anaphase inhibitors, mitotic cyclins, and spindle-associated proteins ensuring that events of mitosis take place in proper sequence. APC3 contains a tetratricopeptide repeat (TPR) region and interacts with mitotic checkpoint proteins including Mad2, p55CDC and BUBR1.

Synonyms

APC3, HNUC, NUC2, ANAPC3, CDC27Hs, D0S1430E, D17S978E, Cell division cycle protein 27 homolog, Anaphase-promoting complex subunit 3, APC3

Gene Name

CDC27

UniProt

P30260

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

APC3 antibody was raised against a 19 amino acid synthetic peptide near the carboxy terminus of human APC3. The immunogen is located within the last 50 amino acids of APC3.

Clonality

Polyclonal

Applications

ELISA, WB, IHC-P

Field of Research

Cancer, Cell Cycle

Purification

APC3 Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.

Storage Conditions

APC3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Observed Molecular Weight

91867 MW

Gene Name Synonym

Cell division cycle 27 homolog (S. cerevisiae)

Subcellular Location

Nucleus.

Prediction Reactivity

Bovine

Protein Name

Cell division cycle 27 homolog (S. cerevisiae)

Isotype

IgG

Contents

APC3 Antibody is supplied in PBS containing 0.02% sodium azide.