Anti-PERP Antibody

About this product

Boster Bio Anti-PERP Antibody (Catalog # A03926) . Tested in ELISA, WB, ICC applications. This antibody reacts with Human.

Specifications

Catalog number

A03926

Size / count

0.1 mg

Dry ice

No

Hazardous

No

Discontinued

No

Background

The p53 tumor-suppressor gene integrates numerous signals that control cell life and death. Several novel molecules involved in p53 network, including Chk2, p53R2, p53AIP1, Noxa, PIDD, PID/MTA2, MTBP and PERP, were identified and their genes were cloned recently. PERP, also termed PIGPC1 and THW, is a plasma membrane protein. p53 binds to the promoter of PERP and transcriptionally activates PERP gene then the translated PERP protein mediates the p53 induced apoptosis. The expression of PERP causes cell death. PERP is a mediator of p53 induced apoptosis. PERP has sequence similarity to PMP-22/gas3 and is a new member of the PMP-22/gas3 family.

Synonyms

THW, KCP1, PIGPC1, KRTCAP1, 1110017A08Rik, Krtcap1, p53 apoptosis effector related to PMP-22, Keratinocyte-associated protein 1, KCP-1

Gene Name

PERP

UniProt

Q9JK95

Host

Rabbit

Reactivity

Human

Immunogen

Anti-PERP antibody was raised against a peptide corresponding to 17 amino acids near the carboxy terminus of human PERP. The immunogen is located within the last 50 amino acids of PERP.

Clonality

Polyclonal

Tissue Specificity

Expressed in the stratified squamous skin epithelium of the skin and the tongue, but not in simple epithelia (at protein level) . Expressed in apoptotic cells.

Applications

ELISA, WB, ICC

Field of Research

Apoptosis

Purification

PERP Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Component of intercellular desmosome junctions. Plays a role in stratified epithelial integrity and cell-cell adhesion by promoting desmosome assembly. Plays a role as an effector in the TP53-dependent apoptotic pathway.

Storage Conditions

PERP antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Observed Molecular Weight

21567 MW

Gene Name Synonym

PERP, TP53 apoptosis effector

Subcellular Location

Cell junction, desmosome

Prediction Reactivity

Rat, Mouse

Protein Name

PERP, TP53 apoptosis effector

Isotype

IgG

Contents

PERP Antibody is supplied in PBS containing 0.02% sodium azide.