Anti-Protein AATF AATF Antibody

About this product

Boster Bio Anti-Protein AATF AATF Antibody (Catalog # A03945) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse.

Specifications

Catalog number

A03945

Size / count

0.1 mg

Dry ice

No

Hazardous

No

Discontinued

No

Background

AATF (apoptosis antagonizing transcription factor) was initially discovered as an interaction partner of ZIP kinase (ZIPK), a member of death-associated protein (DAP) kinase family of pro-apoptotic serine/threonine kinases. AATF is a phosphoprotein containing an acidic region and a putative leucine zipper domain and nuclear localization signal, features which are typical of transcription factors. AATF inhibits the ZIPK-mediated pro-apoptotic pathway and may activate other anti-apoptotic pathways. Recently, it has also been shown to protect neural cells against oxidative damage induced by amyloid b-peptide and to inhibit aberrant production of the beta-peptide by interacting with Par-4 (prostate apoptosis response-4), another pro-apoptotic leucine zipper protein that is associated with neuronal degeneration in Alzheimer's disease (AD), suggesting that AATF may have potential therapeutic applications in both familial and sporadic forms of AD.

Synonyms

DED, BFR2, CHE1, CHE-1, DED, HSPC277, Protein AATF, Apoptosis-antagonizing transcription factor

Gene Name

AATF

UniProt

Q9NY61

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

AATF antibody was raised against a 12 amino acid synthetic peptide from near the carboxy terminus of human AATF. The immunogen is located within the last 50 amino acids of AATF.

Clonality

Polyclonal

Tissue Specificity

Ubiquitously expressed. Expressed at high levels in brain, heart, kidney, placenta and thymus.

Applications

ELISA, WB, IHC-P, IF

Field of Research

Apoptosis

Purification

AATF Antibody is immunoaffinity purified IgG.

Concentration

1 mg/mL

Form

Liquid

Function

May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date.

Storage Conditions

AATF antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Observed Molecular Weight

63133 MW

Gene Name Synonym

Apoptosis antagonizing transcription factor

Subcellular Location

Nucleus, nucleolus

Protein Name

Apoptosis antagonizing transcription factor

Isotype

IgG

Contents

AATF Antibody is supplied in PBS containing 0.02% sodium azide.