Anti-Cdc42-interacting protein 4 TRIP10 Antibody

About this product

Boster Bio Anti-Cdc42-interacting protein 4 TRIP10 Antibody catalog # A03963. Tested in WB, ICC/IF applications. This antibody reacts with Human, Mouse.

Specifications

Catalog number

A03963

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

Cdc42-interacting protein 4; Protein Felic; Salt tolerant protein; hSTP; Thyroid receptor-interacting protein 10; TR-interacting protein 10; TRIP-10; TRIP10; CIP4, STOT, STP

Gene Name

TRIP10

UniProt

Q15642

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

Recombinant fusion protein of human TRIP10 (NP_004231.1) .

Clonality

Polyclonal

Tissue Specificity

Expressed in brain, colon, heart, kidney, liver, lung, megakaryocyte, ovary, pancreas, peripheral blood lymphocytes, placenta, prostate, skeletal muscle, small intestine, spleen, testis, thymus and trachea.

Applications

WB, ICC, IF

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Concentration

1 mg/mL

Form

Liquid

Function

Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling (By similarity) . Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by recruiting WASL/N- WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells. May be required for the lysosomal retention of FASLG/FASL.

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

68352 MW

Gene Name Synonym

Cdc42-interacting protein 4

Subcellular Location

Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Lysosome. Golgi apparatus. Cell membrane. Cell projection, phagocytic cup. Translocates to the plasma membrane in response to insulin stimulation, and this may require active RHOQ (By similarity) . Localizes to cortical regions coincident with F- actin, to lysosomes and to sites of phagocytosis in macrophages. Also localizes to the Golgi, and this requires AKAP9. .

Protein Name

Cdc42-interacting protein 4

Contents

Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2