Anti-OASL Antibody

About this product

Boster Bio Anti-OASL Antibody (Catalog # A04123) . Tested in ELISA, WB, ICC, IF applications. This antibody reacts with Human, Mouse, Rat.

Specifications

Catalog number

A04123

Size / count

0.1 mg

Dry ice

No

Hazardous

No

Discontinued

No

Background

OASL (2'-5'-oligoadenylate synthetase-like), also known as p59OASL or TRIP14 (thyroid receptor-interacting protein 14), is a 514 amino acid protein that exists as two alternatively spliced isoforms, designated p56 and p30, and contains two ubiquitin-like domains (1) . It is widely expressed in a variety of tissues and interacts with the ligand binding domain of the thyroid receptor (TR) and is able to bind double-stranded RNA and DNA, possibly playing a role in RNA degradation and the overall inhibition of protein synthesis (2-3) . Methyl CpG-binding protein 1 (MBD1), which functions as a transcriptional repressor, was identified as a strong p59 OASL interactor (4) .

Synonyms

OASLd, TRIP14, TRIP-14, p59OASL, p59 OASL, p59-OASL, Thyroid receptor-interacting protein 14, TR-interacting protein 14

Gene Name

OASL

UniProt

Q15646

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

OASL antibody is human, mouse and rat reactive.

Immunogen

OASL antibody was raised against a 17 amino acid peptide near the amino terminus of human OASL. The immunogen is located within the first 50 amino acids of OASL.

Clonality

Polyclonal

Tissue Specificity

Expressed in most tissues, with the highest levels in primary blood Leukocytes and other hematopoietic system tissues, colon, stomach and to some extent in testis.

Applications

ELISA, WB, ICC, IF

Field of Research

Homeostasis

Purification

OASL antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Does not have 2'-5'-OAS activity, but can bind double- stranded RNA. Displays antiviral activity against encephalomyocarditis virus (EMCV) and hepatitis C virus (HCV) via an alternative antiviral pathway independent of RNase L.

Storage Conditions

OASL antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Observed Molecular Weight

59226 MW

Gene Name Synonym

2'-5'-oligoadenylate synthetase-like

Subcellular Location

Isoform p56: Nucleus, nucleolus. Cytoplasm.

Protein Name

2'-5'-oligoadenylate synthetase-like

Isotype

IgG

Contents

OASL Antibody is supplied in PBS containing 0.02% sodium azide.