Anti-PIP4K2A Antibody (C-term)

About this product

Boster Bio Anti-PIP4K2A Antibody (C-term) (Catalog # A04244-1) . Tested in Flow Cytometry, IHC-P, WB, IF application (s) . This antibody reacts with Human.

Specifications

Catalog number

A04244-1-400ul

Size / count

400 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

Catalyzes the phosphorylation of phosphatidylinositol 5- phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns (4,5) P2) . May exert its function by regulating the levels of PtdIns5P, which functions in the cytosol by increasing AKT activity and in the nucleus signals through ING2. May regulate the pool of cytosolic PtdIns5P in response to the activation of tyrosine phosphorylation. May negatively regulate insulin- stimulated glucose uptake by lowering the levels of PtdIns5P. May be involved in thrombopoiesis, and the terminal maturation of megakaryocytes and regulation of their size.

Synonyms

Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha, 1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha, Diphosphoinositide kinase 2-alpha, PIP5KIII, Phosphatidylinositol 5-phosphate 4-kinase type II alpha, PI (5) P 4-kinase type II alpha, PIP4KII-alpha, PtdIns (4) P-5-kinase B isoform, PtdIns (4) P-5-kinase C isoform, PtdIns (5) P-4-kinase isoform 2-alpha, PIP4K2A, PIP5K2, PIP5K2A

Gene Name

PIP4K2A

UniProt

P48426

Host

Rabbit

Reactivity

Human

Immunogen

This PIP4K2A antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 329-363 amino acids from the C-terminal region of human PIP4K2A.

Clonality

Polyclonal

Tissue Specificity

Expressed ubiquitously, with high levels in the brain. Present in most tissues, except notably skeletal muscle and small intestine.

Applications

Flow Cytometry, IHC-P, WB, IF

Field of Research

Metabolism, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Function

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Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Observed Molecular Weight

46225 Da

Subcellular Location

Cell membrane {ECO:0000250|UniProtKB:O70172}. Nucleus. Lysosome {ECO:0000250|UniProtKB:O70172}. Cytoplasm. Photoreceptor inner segment {ECO:0000250|UniProtKB:O70172}. Cell projection, cilium, photoreceptor outer segment {ECO:0000250|UniProtKB:O70172}. Note=May translocate from the cytosol to the cell membrane upon activation of tyrosine phosphorylation. May translocate from the inner to the outer segments of the rod photoreceptor cells in response to light (By similarity) Localization to the nucleus is modulated by the interaction with PIP4K2B. {ECO:0000250|UniProtKB:O70172, ECO:0000269|PubMed:20583997}

Prediction Reactivity

Pig

Isotype

Rabbit IgG

Contents

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.