Anti-Homeobox protein Meis2 MEIS2 Antibody

About this product

Boster Bio Anti-Homeobox protein Meis2 MEIS2 Antibody catalog # A04264. Tested in WB applications. This antibody reacts with Mouse, Rat.

Specifications

Catalog number

A04264

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

Homeobox protein Meis2; Meis1-related protein 1; MEIS2; MRG1

Gene Name

MEIS2

UniProt

O14770

Host

Rabbit

Reactivity

Mouse, Rat

Immunogen

Recombinant fusion protein of human MEIS2 (NP_733776.1) .

Clonality

Polyclonal

Tissue Specificity

Expressed in various tissues. Expressed at high level in the lymphoid organs of hematopoietic tissues. Also expressed in some regions of the brain, such as the putamen.

Applications

WB

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Concentration

1 mg/mL

Form

Liquid

Function

Involved in transcriptional regulation. Binds to HOX or PBX proteins to form dimers, or to a DNA-bound dimer of PBX and HOX proteins and thought to have a role in stabilization of the homeoprotein-DNA complex. Isoform 3 is required for the activity of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element; MEIS2 is not involved in complex DNA-binding. Probably in complex with PBX1, is involved in transcriptional regulation by KLF4. Isoform 3 and isoform 4 can bind to a EPHA8 promoter sequence containing the DNA motif 5'-CGGTCA-3'; in cooperation with a PBX protein (such as PBX2) is proposed to be involved in the transcriptional activation of EPHA8 in the developing midbrain. May be involved in regulation of myeloid differentiation. Can bind to the DNA sequence 5'-TGACAG-3'in the activator ACT sequence of the D (1A) dopamine receptor (DRD1) promoter and activate DRD1 transcription; isoform 5 cannot activate DRD1 transcription.

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

51790 MW

Applications Notes

WB: 1:500-1:2000

Gene Name Synonym

Homeobox protein Meis2

Subcellular Location

Nucleus

Protein Name

Homeobox protein Meis2

Contents

Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2