Anti-TYSY Antibody (C-term)

About this product

Boster Bio Anti-TYSY Antibody (C-term) (Catalog # A04320-3) . Tested in Flow Cytometry, IF, IHC-P, WB application (s) . This antibody reacts with Human.

Specifications

Catalog number

A04320-3-80ul

Size / count

80 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs.

Synonyms

Thymidylate synthase, TS, TSase, TYMS, TS

Gene Name

TYMS

UniProt

P04818

Host

Rabbit

Reactivity

Human

Immunogen

This TYSY antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 265-294 amino acids from the C-terminal region of human TYSY.

Clonality

Polyclonal

Applications

Flow Cytometry, IF, IHC-P, WB

Field of Research

Metabolism, Mitochondria

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Function

Catalyzes the reductive methylation of 2'-deoxyuridine 5'- monophosphate (dUMP) to thymidine 5'-monophosphate (dTMP), using the cosubstrate, 5,10- methylenetetrahydrofolate (CH2H4folate) as a 1- carbon donor and reductant and contributes to the de novo mitochondrial thymidylate biosynthesis pathway.

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Observed Molecular Weight

35716 Da

Subcellular Location

Nucleus. Cytoplasm. Mitochondrion. Mitochondrion matrix. Mitochondrion inner membrane

Isotype

Rabbit IgG

Contents

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.