Anti-Kif 7 Monoclonal Antibody

About this product

Boster Bio Anti-Kif 7 Monoclonal Antibody catalog # A04321. Tested in IHC, IF applications. This antibody reacts with Human, Mouse, Rat.

Specifications

Catalog number

A04321

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

Kinesin-like protein KIF7; KIF7; UNQ340/PRO539

Gene Name

KIF7

UniProt

Q2M1P5

Host

Mouse

Reactivity

Human, Mouse, Rat

Immunogen

Synthetic Peptide of Kif 7

Clonality

Monoclonal

Clone

Clone: 3F8

Tissue Specificity

Embryonic stem cells, melanotic melanoma and Jurkat T-cells. Expressed in heart, lung, liver, kidney, testis, retina, placenta, pancreas, colon, small intestin, prostate and thymus. .

Applications

IHC, IF

Purification

Protein A purified

Sensitivity

<10pg/ml

Concentration

1 mg/mL

Form

Liquid

Function

Essential for hedgehog signaling regulation: acts as both a negative and positive regulator of sonic hedgehog (Shh) and Indian hedgehog (Ihh) pathways, acting downstream of SMO, through both SUFU-dependent and -independent mechanisms (PubMed:21633164) . Involved in the regulation of microtubular dynamics. Required for proper organization of the ciliary tip and control of ciliary localization of SUFU-GLI2 complexes (By similarity) . Required for localization of GLI3 to cilia in response to Shh. Negatively regulates Shh signaling by preventing inappropriate activation of the transcriptional activator GLI2 in the absence of ligand. Positively regulates Shh signaling by preventing the processing of the transcription factor GLI3 into its repressor form. In keratinocytes, promotes the dissociation of SUFU-GLI2 complexes, GLI2 nuclear translocation and Shh signaling activation (By similarity) . Involved in the regulation of epidermal differentiation and chondrocyte development (By similarity) . .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

150587 MW

Gene Name Synonym

Kinesin-like protein KIF7

Subcellular Location

Cell projection, cilium . Localizes to the cilium tip.

Isotype

IgG1

Contents

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.