Anti-Frizzled-7 FZD7 Antibody

About this product

Boster Bio Anti-Frizzled-7 FZD7 Antibody catalog # A04391. Tested in WB, Flow Cytometry, IF, ELISA applications. This antibody reacts with Human, Mouse.

Specifications

Catalog number

A04391

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

Frizzled-7; Fz-7; hFz7; FzE3; FZD7

Gene Name

FZD7

UniProt

O75084

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

The antiserum was produced against synthesized peptide derived from human FZD7. AA range:45-94

Clonality

Polyclonal

Tissue Specificity

High expression in adult skeletal muscle and fetal kidney, followed by fetal lung, adult heart, brain, and placenta. Specifically expressed in squamous cell esophageal carcinomas.

Applications

WB, Flow Cytometry, IF, ELISA

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/mL

Form

Liquid

Function

Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

63620 MW

Gene Name Synonym

Frizzled-7

Subcellular Location

Cell membrane

Protein Name

Frizzled-7

Isotype

IgG

Contents

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.