Anti-GITRL TNFSF18 Antibody

About this product

Boster Bio Anti-GITRL TNFSF18 Antibody (Catalog # A04408) . Tested in ELISA, WB applications. This antibody reacts with Human, Mouse.

Specifications

Catalog number

A04408

Size / count

0.1 mg

Dry ice

No

Hazardous

No

Discontinued

No

Background

The tumor necrosis factor (TNF) and TNF receptor (TNFR) gene superfamilies regulate numerous biological functions including cell proliferation, differentiation, and survival through regulating the activation of the transcription factor NF-κB and various mitogen-activated protein kinases. The glucocorticoid-induced tumor necrosis factor receptor (GITR) is an emerging member of this family that is expressed on CD4+ CD25+ regulatory T cells and appears to have crucial immune regulation functions. Its ligand GITRL is expressed in endothelial and antigen-presenting cells and can activate NF-κB, induce both pro- and anti-apoptotic effects, inhibit the suppressive activity of regulatory T cells, and co-stimulate responder T cells through GITR. Dominant negative forms of NIK and TRAF2 expressed in transfected 293 cells substantially inhibited NF-κB activation, suggesting that the GITRL-GITR pathway involves both NIK and TRAF2.

Synonyms

TL6, AITRL, GITRL, hGITRL, TL6, UNQ149/PRO175, Tumor necrosis factor ligand superfamily member 18, Activation-inducible TNF-related ligand

Gene Name

TNFSF18

UniProt

Q9UNG2

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

GITRL antibody was raised against purified recombinant human GITR ligand.

Clonality

Polyclonal

Tissue Specificity

Expressed at high levels in the small intestine, ovary, testis, kidney and endothelial cells.

Applications

ELISA, WB

Field of Research

Chemokines, Cytokines

Purification

GITRL Antibody is Protein A purified.

Concentration

1 mg/mL

Form

Liquid

Function

Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T- cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1 (PubMed:23892569) . Promotes leukocyte adhesion to endothelial cells (PubMed:23892569) . Regulates migration of monocytes from the splenic reservoir to sites of inflammation (By similarity) .

Storage Conditions

GITRL antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Observed Molecular Weight

22724 MW

Gene Name Synonym

Tumor necrosis factor (ligand) superfamily, member 18

Subcellular Location

Cell membrane

Protein Name

Tumor necrosis factor (ligand) superfamily, member 18

Isotype

IgG

Contents

GITRL Antibody is supplied in PBS containing 0.02% sodium azide.