Anti-Tyrosine-protein kinase BAZ1B BAZ1B Antibody

About this product

Boster Bio Anti-Tyrosine-protein kinase BAZ1B BAZ1B Antibody catalog # A04438. Tested in WB, IHC applications. This antibody reacts with Human, Mouse, Rat.

Specifications

Catalog number

A04438

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

Tyrosine-protein kinase BAZ1B;2.7.10.2; Bromodomain adjacent to zinc finger domain protein 1B; Williams syndrome transcription factor; Williams-Beuren syndrome chromosomal region 10 protein; Williams-Beuren syndrome chromosomal region 9 protein; hWALp2; BAZ1B; WBSC10, WBSCR10, WBSCR9, WSTF

Gene Name

BAZ1B

UniProt

Q9UIG0

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant fusion protein of human WSTF (NP_115784.1) .

Clonality

Polyclonal

Tissue Specificity

Ubiquitously expressed with high levels of expression in heart, brain, placenta, skeletal muscle and ovary.

Applications

WB, IHC

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Concentration

1 mg/mL

Form

Liquid

Function

Atypical tyrosine-protein kinase that plays a central role in chromatin remodeling and acts as a transcription regulator. Involved in DNA damage response by phosphorylating 'Tyr-142' of histone H2AX (H2AXY142ph) . H2AXY142ph plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Essential component of the WICH complex, a chromatin remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure. The WICH complex regulates the transcription of various genes, has a role in RNA polymerase I and RNA polymerase III transcription, mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes. In the complex, it mediates the recruitment of the WICH complex to replication foci during DNA replication.

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

170903 MW

Gene Name Synonym

Tyrosine-protein kinase BAZ1B

Subcellular Location

Nucleus

Protein Name

Tyrosine-protein kinase BAZ1B

Contents

Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2