Anti-BHLHB3 BHLHE41 Antibody

About this product

Boster Bio Anti-BHLHB3 BHLHE41 Antibody (Catalog# A04668) . Tested in WB, IHC, ICC, IF, ELISA applications. This antibody reacts with Human, Mouse, Rat.

Specifications

Catalog number

A04668

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

BHLHE41; BHLHB3; DEC2; SHARP1; Class E basic helix-loop-helix protein 41; bHLHe41; Class B basic helix-loop-helix protein 3; bHLHb3; Differentially expressed in chondrocytes protein 2; hDEC2; Enhancer-of-split and hairy-related protein 1; S

Gene Name

BHLHE41

UniProt

Q9C0J9

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

A peptide derived from human BHLHB3. Immunogen sequence location: 1-50

Clonality

Polyclonal

Tissue Specificity

Highly expressed in skeletal muscle and brain, moderately expressed in pancreas and heart, weakly expressed in placenta, lung, liver and kidney.

Applications

WB, IHC, ICC, IF, ELISA

Field of Research

Cancer, Cancer Metabolism, Domain Families, Epigenetics and Nuclear Signaling, Hlh/Leucine Zipper, Neural Signal Transduction, Neurology Process, Neuroscience, Response To Hypoxia, Transcription, Transcription Factors

Purification

The antibody was purified from rabbit antiserum by affinity-chromatography using immunogen.

Concentration

0.5-1mg/mL, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Form

Liquid

Function

Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes. Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop) . Both these loops are interlocked as it represses the expression of PER1 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1 heterodimer by competing for the binding to E-box elements (5'-CACGTG-3') found within the promoters of its target genes. Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2. Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA/B/G, NR1H3/LXRA, NR1H4 and VDR transactivation activity.

Storage Conditions

Store at -20°C for one year. For short-term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

50498 MW

Gene Name Synonym

Class E basic helix-loop-helix protein 41

Subcellular Location

Nucleus.

Isotype

Rabbit IgG

Contents

PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.