Anti-JMJD2C Antibody (C-term)

Catalog number A04689-400ul

Price for A04689-400ul

Size / count 400 µL

About this product

Boster Bio Anti-JMJD2C Antibody (C-term) (Catalog # A04689) . Tested in WB, Flow Cytometry application (s) . This antibody reacts with Human, Mouse.

Specifications

Catalog number: A04689-400ul
Size / count: 400 µL
Dry ice: No
Hazardous: No
Discontinued: No
Background: This gene is a member of the Jumonji domain 2 (JMJD2) family and encodes a protein with one JmjC domain, one JmjN domain, two PHD-type zinc fingers, and two Tudor domains. This nuclear protein functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form. Chromosomal aberrations and increased transcriptional expression of this gene are associated with esophageal squamous cell carcinoma. Alternative splicing results in multiple transcript variants.
Synonyms: Lysine-specific demethylase 4C, 11411-, Gene amplified in squamous cell carcinoma 1 protein, GASC-1 protein, JmjC domain-containing histone demethylation protein 3C, Jumonji domain-containing protein 2C, KDM4C, GASC1, JHDM3C, JMJD2C, KIAA0780
Gene Name: KDM4C
UniProt: Q9H3R0
Host: Rabbit
Reactivity: Human, Mouse
Immunogen: This JMJD2C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1023-1056 amino acids from the C-terminal region of human JMJD2C.
Clonality: Polyclonal
Tissue Specificity: Overexpressed in several esophageal squamous cell carcinomas (ESCs) .
Applications: WB, Flow Cytometry
Field of Research: Cancer
Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.
Function: Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate.
Storage Conditions: Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Observed Molecular Weight: 119982 Da
Subcellular Location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00537}.
Isotype: Rabbit IgG
Contents: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

Frequently Asked Questions

What is the catalog number for Anti-JMJD2C Antibody (C-term)?

The catalog number for Anti-JMJD2C Antibody (C-term) is A04689-400ul.

What sizes are available for Anti-JMJD2C Antibody (C-term)?

Anti-JMJD2C Antibody (C-term) is available in the following size(s): 400 µL.

Is Anti-JMJD2C Antibody (C-term) in stock?

Anti-JMJD2C Antibody (C-term) is currently made to order / not held in immediate stock. Contact us for lead time.

Where can I find the safety data sheet (SDS/MSDS) for Anti-JMJD2C Antibody (C-term)?

The safety data sheet for Anti-JMJD2C Antibody (C-term) is available here: https://www.bosterbio.com/msds?sku=A04689.

What is Anti-JMJD2C Antibody (C-term) used for?

Boster Bio Anti-JMJD2C Antibody (C-term) (Catalog # A04689) . Tested in WB, Flow Cytometry application (s) . This antibody reacts with Human, Mouse.

What should I check when this product first arrives?

Inspect the package immediately for transportation damage, ice loss, leakage, or breakage. Report any issues right away with photos and your order reference; our specialists will determine whether the product is still usable or needs replacing.

Does this cell line or biologic require a Material Transfer Agreement (MTA)?

Some products, including certain cell lines, plasmids, and tissue cultures, are subject to intellectual property terms and may require an MTA before we can ship. We’ll inform you in advance if this product requires one, and additional handling fees may apply.

What should I do if I need to report a performance issue with a specific lot of this product?

Provide the catalogue number, product name, lot number, and your experimental results to our technical support team. They’ll investigate and, if needed, escalate to the manufacturer, provided the product was used before expiry and stored correctly.