Anti-TEM1 CD248 Antibody

About this product

Boster Bio Anti-TEM1 CD248 Antibody (Catalog # A04735) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human.

Specifications

Catalog number

A04735

Size / count

0.1 mg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Tumor endothelial marker (TEM) 1 was originally identified as a human embryonic fibroblast-specific antigen and was later determined to be endosialin, a single-pass transmembrane glycoprotein that has multiple extracellular domains, including three EGF-like domains, a sushi-like domain, and a C lectin-like domain. TEM proteins are significantly up-regulated during angiogenesis and neoangiogenesis that are crucial for the growth of solid tumors. While TEM1 is not required for angiogenesis during fetal development, postnatal growth or wound healing, it plays a role in tumor growth, invasion, and metastasis. Fibronectin and collagen types I and IV act as specific ligands of TEM1, leading to suggestions that these molecules may cause changes in the extracellular matrix, cell adhesion and migration during tumor invasion.

Synonyms

TEM1, CD164L1, CD248, Endosialin, Tumor endothelial marker 1

Gene Name

CD248

UniProt

Q9HCU0

Host

Rabbit

Reactivity

Human

Cross Reactivity

At least two isoforms of TEM1 are known to exist; this antibody recognizes both isoforms.

Immunogen

Anti-TEM-1 antibody was raised against a peptide corresponding to 14 amino acids near the carboxy terminus of human TEM-1. The immunogen is located within the last 50 amino acids of TEM-1.

Clonality

Polyclonal

Tissue Specificity

Expressed in tumor endothelial cells but absent or barely detectable in normal endothelial cells. Expressed in metastatic lesions of the liver and during angiogenesis of corpus luteum formation and wound healing. Expressed in vascular endothelial cells of malignant tumors but not in normal blood vessels. Expressed in stromal fibroblasts.

Applications

ELISA, WB, IHC-P, IF

Field of Research

Homeostasis, Cancer

Purification

TEM1 Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

May play a role in tumor angiogenesis.

Storage Conditions

TEM1 antibody can be stored at 4°C up to one year. Antibodies should not be exposed to prolonged high temperatures.

Observed Molecular Weight

80859 MW

Gene Name Synonym

CD248 molecule, endosialin

Subcellular Location

Membrane ; Single-pass type I membrane protein .

Prediction Reactivity

Mouse, Rat

Protein Name

CD248 molecule, endosialin

Isotype

IgG

Contents

TEM1 Antibody is supplied in PBS containing 0.02% sodium azide.