Anti-RHAMM HMMR Antibody

About this product

Boster Bio Anti-RHAMM HMMR Antibody (Catalog # A05056) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.

Specifications

Catalog number

A05056

Size / count

0.1 mg

Dry ice

No

Hazardous

No

Discontinued

No

Background

The hyaluronan-mediated motility receptor, also known as RHAMM, was initially identified as a soluble protein that could be released by sub-confluent migrating cells, promoting cell motility and invasion via interactions with hyaluronan (HA) and the cell surface. While RHAMM is normally poorly expressed in most normal tissues and is not required for embryonic development or normal cell homeostasis functions, its expression is increased during wound repair in response to hypoxia and fibrogenic factors. However, its overexpression is transforming in multiple types of cancers and is required for maintaining RAS transformation. RHAMM associates with BRCA1 and BARD1, attenuating the mitotic-spindle-promoting activity of RHAMM, which may contribute to tumor progression by promoting genomic instability.

Synonyms

CD168, IHABP, RHAMM, Hyaluronan mediated motility receptor, Intracellular hyaluronic acid-binding protein

Gene Name

HMMR

UniProt

O75330

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

RHAMM antibody was raised against a 18 amino acid synthetic peptide near the amino terminus of human RHAMM. The immunogen is located within amino acids 80 - 130 of RHAMM.

Clonality

Polyclonal

Applications

ELISA, WB, IHC-P, IF

Field of Research

Cancer, Cell Cycle

Purification

RHAMM Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Receptor for hyaluronic acid (HA) (By similarity) . Involved in cell motility (By similarity) . When hyaluronan binds to HMMR, the phosphorylation of a number of proteins, including PTK2/FAK1 occurs. May also be involved in cellular transformation and metastasis formation, and in regulating extracellular- regulated kinase (ERK) activity. May act as a regulator of adipogenisis (By similarity) .

Storage Conditions

RHAMM antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Observed Molecular Weight

84100 MW

Gene Name Synonym

Yaluronan-mediated motility receptor

Subcellular Location

Cell surface

Protein Name

Yaluronan-mediated motility receptor

Isotype

IgG

Contents

RHAMM Antibody is supplied in PBS containing 0.02% sodium azide.