Anti-LIMP2 SCARB2 Antibody

About this product

Boster Bio Anti-LIMP2 SCARB2 Antibody (Catalog # A05090) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.

Specifications

Catalog number

A05090

Size / count

0.1 mg

Dry ice

No

Hazardous

No

Discontinued

No

Background

The lysosomal integral membrane protein 2 (LIMP2) is a heavily glycosylated type III transmembrane protein, the majority of which exists in the lumen of the lysosome and a cytoplasmic domain of approximately 20 amino acids. A deficiency of LIMP2 in mice causes uretic pelvic junction obstruction, deafness, and peripheral neuropathy associated with impaired vesicular trafficking and distribution of apically expressed proteins. More recently, LIMP2 was shown to act as a receptor to bind beta-glucocerebrosidase, the enzyme defective in Gaucher disease, a lysosomal storage disorder. LIMP2-deficient mice showed missorted as well as secreted beta-glucocerebrosidase, suggesting that LIMP2 also functions as the mannose-6-phosphate-independent trafficking receptor.

Synonyms

AMRF, EPM4, LGP85, CD36L2, HLGP85, LIMP-2, LIMPII, SR-BII, LIMP2, Lysosome membrane protein 2, 85 kDa lysosomal membrane sialoglycoprotein

Gene Name

SCARB2

UniProt

Q14108

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

LIMP2 antibody was raised against a 16 amino acid synthetic peptide from near the center of human LIMP2. The immunogen is located within amino acids 70 - 120 of LIMP2.

Clonality

Polyclonal

Tissue Specificity

Detected in most adult tissues. Highest levels were found in heart and skeletal muscle. Low levels are found in brain.

Applications

ELISA, WB, IHC-P, IF

Field of Research

Homeostasis

Purification

LIMP2 Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Acts as a lysosomal receptor for glucosylceramidase (GBA) targeting.

Storage Conditions

Antibody can be stored at 4°C up to one year. Antibodies should not be exposed to prolonged high temperatures.

Observed Molecular Weight

54290 MW

Gene Name Synonym

Scavenger receptor class B, member 2

Subcellular Location

Lysosome membrane

Protein Name

Scavenger receptor class B, member 2

Isotype

IgG

Contents

LIMP2 Antibody is supplied in PBS containing 0.02% sodium azide.