Anti-SLAF6 SLAMF6 Antibody

About this product

Boster Bio Anti-SLAF6 SLAMF6 Antibody catalog # A05310. Tested in WB, ELISA applications. This antibody reacts with Human, Mouse.

Specifications

Catalog number

A05310

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

SLAM family member 6; Activating NK receptor; NK-T-B-antigen; NTB-A; CD352; SLAMF6; KALI; UNQ6123/PRO20080

Gene Name

SLAMF6

UniProt

Q96DU3

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

Synthesized peptide derived from human protein at AA range: 20-100

Clonality

Polyclonal

Tissue Specificity

Expressed by all (resting and activated) natural killer cells (NK), T- and B-lymphocytes (PubMed:11489943) . Increased surface expression on T-cells of systemic lupus erythematosus (SLE) patients (PubMed:22184727) .

Applications

WB, ELISA

Purification

SLAF6 antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/mL

Form

Liquid

Function

Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Triggers cytolytic activity only in natural killer cells (NK) expressing high surface densities of natural cytotoxicity receptors (PubMed:11489943, PubMed:16920955) . Positive signaling in NK cells implicates phosphorylation of VAV1. NK cell activation seems to depend on SH2D1B and not on SH2D1A (PubMed:16920955) . In conjunction with SLAMF1 controls the transition between positive selection and the subsequent expansion and differentiation of the thymocytic natural killer T (NKT) cell lineage (By similarity) . Promotes T-cell differentiation into a helper T-cell Th17 phenotype leading to increased IL-17 secretion; the costimulatory activity requires SH2D1A (PubMed:22184727, PubMed:16920955) . Promotes recruitment of RORC to the IL-17 promoter (PubMed:22989874) . In conjunction with SLAMF1 and CD84/SLAMF5 may be a negative regulator of the humoral immune response. In the absence of SH2D1A/SAP can transmit negative signals to CD4 (+) T-cells and NKT cells. Negatively regulates germinal center formation by inhibiting T-cell:B-cell adhesion; the function probably implicates increased association with PTPN6/SHP-1 via ITSMs in absence of SH2D1A/SAP. However, reported to be involved in maintaining B-cell tolerance in germinal centers and in preventing autoimmunity (By similarity) .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

37345 MW

Gene Name Synonym

SLAM family member 6

Subcellular Location

Cell membrane ; Single-pass type I membrane protein .

Protein Name

SLAM family member 6

Isotype

IgG

Contents

Liquid form in PBS containing 50% glycerol, and 0.02% sodium azide.