Anti-Aipl1 Antibody

About this product

Boster Bio Anti-Aipl1 Antibody (Catalog # A05356) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse.

Specifications

Catalog number

A05356

Size / count

0.1 mg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Aipl1 was initially identified as a protein implicated in Leber congenital amaurosis (LCA), an autosomal recessive disorder thought to be caused by the abnormal development of photoreceptors. Aipl1 is a tetratricopeptide repeat protein that is highly homologous to ARA9, a protein involved in the HSP90-mediated nuclear translocation and transactivation of the aryl hydrocarbon receptor. Aipl1 has also been found to function as part of a chaperone heterocomplex, interacting with Hsp90 and Hsp70. Aipl1 also associates with the cell cycle regulator NUB1. It is thought that Aipl1 cooperates with Hsp70 but not Hsp90 to suppress the formation of NUB1 inclusions, and these interactions are necessary in the normal photoreceptor maturation, as mutations that lead to LCA also compromise the interactions with the Hsp chaperones. At least three isoforms of Aipl1 are known to exist.

Synonyms

LCA4, AIPL2, Aryl-hydrocarbon-interacting protein-like 1

Gene Name

AIPL1

UniProt

Q9NZN9

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

Aipl1 antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of the human Aipl1. The immunogen is located within amino acids 290 - 340 of Aipl1.

Clonality

Polyclonal

Tissue Specificity

Highly expressed in retina. Specifically localized to the developing photoreceptor layer and within the photoreceptors of the adult retina.

Applications

ELISA, WB, IHC-P, IF

Field of Research

Homeostasis

Purification

Aipl1 Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

May be important in protein trafficking and/or protein folding and stabilization.

Storage Conditions

Aipl1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Observed Molecular Weight

43903 MW

Gene Name Synonym

Aryl hydrocarbon receptor interacting protein-like 1

Subcellular Location

Cytoplasm

Prediction Reactivity

Rat

Protein Name

Aryl hydrocarbon receptor interacting protein-like 1

Isotype

IgG

Contents

Aipl1 Antibody is supplied in PBS containing 0.02% sodium azide.