Anti-SUV39H2 Antibody

About this product

Boster Bio Anti-SUV39H2 Antibody catalog # A05361. Tested in WB, IHC, IP applications. This antibody reacts with Human, Mouse, Rat.

Specifications

Catalog number

A05361

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

Histone-lysine N-methyltransferase SUV39H2;2.1.1.43; Histone H3-K9 methyltransferase 2; H3-K9-HMTase 2; Lysine N-methyltransferase 1B; Suppressor of variegation 3-9 homolog 2; Su (var) 3-9 homolog 2; SUV39H2; KMT1B

Gene Name

SUV39H2

UniProt

Q9H5I1

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide within Human SUV39H2 aa 350 to the C-terminus.

Clonality

Polyclonal

Applications

WB, IHC, IP

Purification

ProA affinity purified

Concentration

1 mg/mL

Form

Liquid

Function

Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys- 9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as cell cycle regulation, transcriptional repression and regulation of telomere length. May participate in regulation of higher-order chromatin organization during spermatogenesis. Recruited by the large PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation.

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

46682 MW

Gene Name Synonym

Histone-lysine N-methyltransferase SUV39H2

Subcellular Location

Nucleus . Chromosome, centromere . Associates with centromeric constitutive heterochromatin. .

Protein Name

Histone-lysine N-methyltransferase SUV39H2

Contents

Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2