Anti-TBX6 Antibody (Center W158)

About this product

Boster Bio Anti-TBX6 Antibody (Center W158) (Catalog # A05398-1) . Tested in WB, Flow Cytometry application (s) . This antibody reacts with Human, Mouse.

Specifications

Catalog number

A05398-1-80ul

Size / count

80 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. Knockout studies in mice indicate that this gene is important for specification of paraxial mesoderm structures.

Synonyms

T-box transcription factor TBX6, T-box protein 6, TBX6

Gene Name

TBX6

UniProt

O95947

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

This TBX6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 143-172 amino acids from the Central region of human TBX6.

Clonality

Polyclonal

Tissue Specificity

Expressed in fetal tail bud, posterior spinal tissue, intervertebral disk and testis. Also expressed in adult testis, kidney, lung, muscle and thymus

Applications

WB, Flow Cytometry

Field of Research

Developmental Biology, Signal Transduction

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Function

T-box transcription factor that plays an essential role in the determination of the fate of axial stem cells: neural vs mesodermal. Acts in part by down-regulating, a specific enhancer (N1) of SOX2, to inhibit neural development. Seems to play also an essential role in left/right axis determination and acts through effects on Notch signaling around the node as well as through an effect on the morphology and motility of the nodal cilia (By similarity) .

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Observed Molecular Weight

47045 Da

Subcellular Location

Nucleus {ECO:0000255|PROSITE-ProRule:PRU00201}.

Prediction Reactivity

Bovine, Rat

Isotype

Rabbit IgG

Contents

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.