Anti-SIVA SIVA1 Antibody

About this product

Boster Bio Anti-SIVA SIVA1 Antibody (Catalog # A05419) . Tested in ELISA, WB, IF applications. This antibody reacts with Human, Mouse.

Specifications

Catalog number

A05419

Size / count

0.1 mg

Dry ice

No

Hazardous

No

Discontinued

No

Background

SIVA plays an important role in the apoptotic pathway induced by the CD27 antigen, a member of the tumor necrosis factor receptor (TFNR) superfamily. SIVA is a small cysteine-rich protein with a unique N-terminal amphipathic helical region, a death domain homology region (DDHR) and a C-terminal cysteine-rich B-box-like or zinc-finger-like structure. The DDHR domain binds to CD27 and induces apoptosis in T cells through a caspase-dependent mitochondrial pathway. SIVA inhibits BCL2L1 isoform Bcl-xL anti-apoptotic activity and inhibits activation of NFκ-B and promotes T-cell receptor-mediated apoptosis. SIVA represents a potential therapeutic target for the treatment of neuronal cell death diseases.

Synonyms

SIVA, CD27BP, Siva-1, Siva-2, SIVA, Apoptosis regulatory protein Siva, CD27-binding protein

Gene Name

SIVA1

UniProt

O15304

Host

Chicken

Reactivity

Human, Mouse

Immunogen

SIVA antibody was raised against a 16 amino acid synthetic peptide near the amino terminus of human SIVA. The immunogen is located within the first 50 amino acids of SIVA.

Clonality

Polyclonal

Tissue Specificity

Ubiquitous. Mostly expressed in thymus, testis, ovary, prostate, small intestine and spleen and less in colon.

Applications

ELISA, WB, IF

Field of Research

Apoptosis

Purification

SIVA Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl-x (L) anti-apoptotic activity. Inhibits activation of NF-kappa- B and promotes T-cell receptor-mediated apoptosis.

Storage Conditions

SIVA antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Observed Molecular Weight

18695 MW

Gene Name Synonym

SIVA1, apoptosis-inducing factor

Subcellular Location

Cytoplasm

Prediction Reactivity

Rat

Protein Name

SIVA1, apoptosis-inducing factor

Isotype

IgY

Contents

SIVA Antibody is supplied in PBS containing 0.02% sodium azide.