Anti-Kynurenine 3-monooxygenase KMO Antibody

About this product

Boster Bio Anti-Kynurenine 3-monooxygenase KMO Antibody (Catalog # A05469) . Tested in WB applications. This antibody reacts with Human, Mouse.

Specifications

Catalog number

A05469

Size / count

100 µg

Dry ice

Yes

Hazardous

No

Discontinued

No

Background

Kynurenine 3-monooxygenase (KMO) catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn) . The enzyme is required for synthesis of quinolinic acid. Quinolinic acid is a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Anti-KMO antibodies are ideal for researchers interested in Apoptosis, Neurodegeneration, and Neuroscience research.

Synonyms

KMO, kynurenine 3-monooxygenase, kynurenine 3-hydroxylase

Gene Name

KMO

UniProt

O15229

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

KMO affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to an internal region surrounding 300-400aa of the mouse KMO chain.

Clonality

Polyclonal

Tissue Specificity

Highest levels in placenta and liver. Detectable in kidney.

Applications

ELISA, IHC, IF, WB

Purification

Anti-KMO was affinity purified from monospecific antiserum by immunoaffinity chromatography. This antibody is specific towards Kynurenine 3-monooxygenase (KMO) . A BLAST analysis was used to suggest cross-reactivity with Mouse based on 100% sequence homology. Cross-reactivity with KMO from other sources has not been determined.

Concentration

1.02 mg/mL by UV absorbance at 280 nm

Form

Liquid (sterile filtered)

Function

Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn) . Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract.

Shipping Conditions

Dry Ice Shipping

Storage Conditions

Store vial at -20°C prior to opening. Aliquot contents and freeze at -20°C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. Expiration date is six (6) months from date of opening.

Observed Molecular Weight

55810 MW

Gene Name Synonym

Kynurenine 3-monooxygenase

Subcellular Location

Mitochondrion outer membrane ; Multi-pass membrane protein.

Isotype

IgG

Contents

0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2, 50% (v/v) Glycerol