Anti-Mitochondrial Rho GTPase 1 RHOT1 Antibody

About this product

Boster Bio Anti-Mitochondrial Rho GTPase 1 RHOT1 Antibody (Catalog # A05928) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.

Specifications

Catalog number

A05928

Size / count

0.1 mg

Dry ice

No

Hazardous

No

Discontinued

No

Background

The Ras homolog family member T1 (RHOT) is an atypical Rho Ca2+-binding GTPase that localizes to the mitochondria (1) . RHOT1, the related protein RHOT2, the adaptor protein Milton, and the PTEN induced putative kinase 1 (PINK1), form a complex that is involved in axonal transport of mitochondria (2,3) . Both PINK1 and Parkin target RHOT1 for phosphorylation and degradation, causing the arrest of mitochondrial motility (4) .

Synonyms

Ras homolog family member T1, mitochondrial Rho GTPase 1, ARHT1, MIRO-1, MIRO1, MIRO

Gene Name

RHOT1

UniProt

Q8IXI2

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

RHOT1 antibody is human, mouse and rat reactive. At least three isoforms of RHOT1 are known to exist; this antibody will detect all three isoforms.

Immunogen

RHOT1 antibody was raised against a 15 amino acid peptide near the amino terminus of human RHOT1. The immunogen is located within amino acids 40 - 90 of RHOT1.

Clonality

Polyclonal

Tissue Specificity

Ubiquitously expressed. Expressed at high level in heart and skeletal muscle.

Applications

ELISA, WB, IHC-P, IF

Field of Research

Neuroscience

Purification

RHOT1 antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution.

Storage Conditions

RHOT1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Observed Molecular Weight

70784 MW

Gene Name Synonym

Ras homolog family member T1

Subcellular Location

Mitochondrion outer membrane

Prediction Reactivity

Bovine, Chicken

Protein Name

Ras homolog family member T1

Isotype

IgG

Contents

RHOT1 antibody is supplied in PBS containing 0.02% sodium azide.