Anti-AHSP/Eraf Antibody

About this product

Boster Bio Anti-AHSP/Eraf Antibody (Catalog # A05948) . Tested in IHC, WB applications. This antibody reacts with Human, Mouse.

Specifications

Catalog number

A05948

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

AHSP Antibody detects Alpha hemoglobin stabilizing protein (AHSP) . AHSP acts as a chaperone to prevent the harmful aggregation of alpha-hemoglobin during normal erythroid cell development. AHSP binds free a-globin to promote its folding and inhibit its ability to produce damaging reactive oxygen species. Reduced AHSP levels correlate with increased severity of b-thalassemia in some human cohorts.

Synonyms

AHSP, Alpha-hemoglobin-stabilizing protein (AHSP), Erythroid differentiation-related factor, Erythroid-associated factor, EDRF, ERAF

Gene Name

AHSP

UniProt

Q9NZD4

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

Anti-AHSP Antibody was produced from whole rabbit serum prepared by repeated immunizations with the full length human AHSP protein.

Clonality

Polyclonal

Tissue Specificity

Expressed in blood and bone marrow.

Applications

ELISA, IHC, WB

Field of Research

Cardiovascular, Chaperones, Hematopoietic Progenitors, Myeloid, Protein Trafficking, Signal Transduction, Stem Cells

Purification

Anti-AHSP Antibody is directed against the human AHSP protein. The product was prepared from monospecific antiserum by delipidation and defibrination. A BLAST analysis was used to suggest cross-reactivity with human and mouse. Cross-reactivity with AHSP from other sources have not been determined.

Concentration

115 mg/mL by Refractometry

Form

Lyophilized

Reconstitution

Restore with deionized water (or equivalent) for reconstitution volume of 100 μL

Function

Acts as a chaperone to prevent the harmful aggregation of alpha-hemoglobin during normal erythroid cell development. Specifically protects free alpha-hemoglobin from precipitation. It is predicted to modulate pathological states of alpha-hemoglobin excess such as beta-thalassemia.

Storage Conditions

Store vial at 4°C prior to restoration. For extended storage aliquot contents and freeze at -20°C or below. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. Expiration date is one (1) year from date of opening. (Ship at ambient temperature.)

Observed Molecular Weight

11840 MW

Gene Name Synonym

Alpha-hemoglobin-stabilizing protein

Subcellular Location

Cytoplasm.

Isotype

Antiserum

Contents

0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2, 0.01% (w/v) Sodium Azide