Anti-OLIG1 Antibody

About this product

Boster Bio Anti-OLIG1 Antibody (Catalog # A06108) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human.

Specifications

Catalog number

A06108

Size / count

0.1 mg

Dry ice

No

Hazardous

No

Discontinued

No

Background

The oligodendrocyte transcription factors 1 and 2 (OLIG1 and OLIG2, respectively) make up part of basic helix-loop-helix (bHLH) family of transcription factors that are specifically expressed in zones of the neuroepithelium from which oligodendrocyte precursors emerge (1) . Both OLIG1 and OLIG2 genes are downstream targets of Sonic hedgehog and are expressed exclusively in the central nervous system (2) . OLIG1 is first expressed in the dorsal portion of the p3 progenitor domain of the ventral neural tube while OLIG2 is first observed in the ventral most p3 domain (2) . OLIG1 has been shown to be a SMAD cofactor involved in cell motility induced by transforming growth factor-beta (TGF-beta) (3) .

Synonyms

BHLHB6, BHLHE21, BHLHB6, Oligodendrocyte transcription factor 1, Class B basic helix-loop-helix protein 6, Oligo1

Gene Name

OLIG1

UniProt

Q8TAK6

Host

Rabbit

Reactivity

Human

Cross Reactivity

OLIG1 antibody is human specific. It is predicted to not cross-react with other members of the OLIG family of proteins.

Immunogen

OLIG1 antibody was raised against an 18 amino acid peptide near the amino terminus of human OLIG1. The immunogen is located within amino acids 50 - 100 of OLIG1.

Clonality

Polyclonal

Tissue Specificity

Expressed in the brain, in oligodendrocytes. Strongly expressed in oligodendrogliomas, while expression is weak to moderate in astrocytomas. Expression in glioblastomas is highly variable.

Applications

ELISA, WB, IHC-P, IF

Field of Research

Stem Cells

Purification

OLIG1 antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Promotes formation and maturation of oligodendrocytes, especially within the brain. Cooperates with OLIG2 to establish the pMN domain of the embryonic neural tube (By similarity) .

Storage Conditions

OLIG1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Observed Molecular Weight

27905 MW

Gene Name Synonym

Oligodendrocyte transcription factor 1

Subcellular Location

Nucleus

Prediction Reactivity

Rat, Mouse

Protein Name

Oligodendrocyte transcription factor 1

Isotype

IgG

Contents

OLIG1 Antibody is supplied in PBS containing 0.02% sodium azide.