Anti-Importin subunit alpha-4 KPNA3 Antibody

About this product

Boster Bio Anti-Importin subunit alpha-4 KPNA3 Antibody (Catalog # A06131) . Tested in ELISA, WB, ICC, IF applications. This antibody reacts with Human, Mouse, Rat.

Specifications

Catalog number

A06131

Size / count

0.1 mg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Karyopherin, a cytosolic and heterodimeric protein complex consisting of alpha and beta subunits, is responsible for targeting proteins with nuclear localization signals to the nuclear pore complex by an energy requiring, Ran-dependent mechanism. The alpha subunit and imported substrate enter the nucleus and accumulate in the nucleoplasm, while the beta subunit accumulates at the NPC. KPNA3, the alpha subunit 3 of karyopherin, is silimar to human KPNA2, suggesting that KPNA3 may be involved in the nuclear transport system. It is ubiquitously expressed and recent studies have shown that human KPNA3 may be associated with schizophrenia.

Synonyms

SRP1, SRP4, IPOA4, hSRP1, SRP1gamma, QIP2, Importin subunit alpha-4, Importin alpha Q2, Qip2

Gene Name

KPNA3

UniProt

O00505

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

KPNA3 antibody was raised against a 14 amino acid synthetic peptide near the carboxy end of human KPNA3. The immunogen is located within the last 50 amino acids of KPNA3.

Clonality

Polyclonal

Tissue Specificity

Ubiquitous. Highest levels in heart and skeletal muscle.

Applications

ELISA, WB, ICC, IF

Field of Research

Homeostasis

Purification

KPNA3 Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non- classical NLS. Recognizes NLSs of influenza A virus nucleoprotein probably through ARM repeats 7-9.

Storage Conditions

KPNA3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Observed Molecular Weight

57811 MW

Gene Name Synonym

Karyopherin alpha 3 (importin alpha 4)

Subcellular Location

Cytoplasm . Nucleus .

Protein Name

Karyopherin alpha 3 (importin alpha 4)

Isotype

IgG

Contents

KPNA3 Antibody is supplied in PBS containing 0.02% sodium azide.