Anti-Fn14 TNFRSF12A Antibody

About this product

Boster Bio Anti-Fn14 TNFRSF12A Antibody (Catalog # A06261) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human.

Specifications

Catalog number

A06261

Size / count

0.1 mg

Dry ice

No

Hazardous

No

Discontinued

No

Background

TWEAK is a TNF family member produced by IFN-gamma-stimulated monocytes and induces multiple cell death pathways including caspase-dependent apoptosis and cathepsin B-dependent necrosis. These pathways are mediated by the binding of TWEAK by fibroblast growth factor 14 (Fn14), a member of the TNF receptor superfamily. Yeast two-hybrid experiments have shown that FN14 will bind to the TNFR-associated factors TRAF1, TRAF2, TRAF3, and TRAF5, suggesting that the signaling pathway induced by TWEAK may be mediated by one or more of these adaptor molecules. Fn14 is induced during liver regeneration and is highly expressed in hepatocellular carcinomas. In addition, TWEAK induces liver progenitor cell proliferation, suggesting Fn14 may play a role in hepatocyte growth control and liver neoplasia.

Synonyms

FN14, CD266, TWEAKR, FN14, Tumor necrosis factor receptor superfamily member 12A, Fibroblast growth factor-inducible immediate-early response protein 14, FGF-inducible 14

Gene Name

TNFRSF12A

UniProt

Q9NP84

Host

Rabbit

Reactivity

Human

Immunogen

Fn14 antibody was raised against a human IgG1 Fc-tagged Fn14 protein.

Clonality

Polyclonal

Tissue Specificity

Highly expressed in heart, placenta and kidney. Intermediate expression in lung, skeletal muscle and pancreas.

Applications

ELISA, WB, IHC-P, IF

Field of Research

Apoptosis

Purification

Fn14 Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins.

Storage Conditions

Fn14 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Observed Molecular Weight

13911 MW

Gene Name Synonym

Tumor necrosis factor receptor superfamily, member 12A

Subcellular Location

Membrane; Single-pass type I membrane protein.

Protein Name

Tumor necrosis factor receptor superfamily, member 12A

Isotype

IgG

Contents

Fn14 Antibody is supplied in PBS containing 0.02% sodium azide.