Anti-LZTS1 Antibody (N-term)

About this product

Boster Bio Anti-LZTS1 Antibody (N-term) (Catalog # A06359) . Tested in WB application (s) . This antibody reacts with Human, Mouse.

Specifications

Catalog number

A06359-400ul

Size / count

400 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

This gene encodes a tumor suppressor protein that is ubiquitously expressed in normal tissues. In uveal melanomas, expression of this protein is silenced in rapidly metastasizing and metastatic tumor cells but has normal expression in slowly metastasizing or nonmetastasizing tumor cells. This protein may have a role in cell-cycle control by interacting with the Cdk1/cyclinB1 complex. This gene is located on chromosomal region 8p22. Loss of heterozygosity (LOH) in the 8p arm is a common characteristic of many types of cancer.

Synonyms

Leucine zipper putative tumor suppressor 1, F37/esophageal cancer-related gene-coding leucine-zipper motif, Fez1, LZTS1, FEZ1

Gene Name

LZTS1

UniProt

Q9Y250

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

This LZTS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 77-105 amino acids from the N-terminal region of human LZTS1.

Clonality

Polyclonal

Tissue Specificity

Highly expressed in testis, prostate, spleen, thymus, ovary and brain. Detected at lower levels in heart, placenta, small intestine, colon, liver, kidney, skeletal muscle and pancreas Not detectable in primary tumors from breast and prostate and in many cancer cell lines.

Applications

WB

Field of Research

Cancer, Cell Biology

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Function

Involved in the regulation of cell growth. May stabilize the active CDC2-cyclin B1 complex and thereby contribute to the regulation of the cell cycle and the prevention of uncontrolled cell proliferation. May act as a tumor suppressor.

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Observed Molecular Weight

66613 Da

Applications Notes

WB: 1:1000

Subcellular Location

Cytoplasm. Cell membrane. Cell projection, dendritic spine Postsynaptic density. Synapse Note=Associated with the plasma membrane and with microtubules Detected in dendritic spines, especially in the postsynaptic density (By similarity) .

Isotype

Rabbit IgG

Contents

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.