Anti-Borealin CDCA8 Antibody

About this product

Boster Bio Anti-Borealin CDCA8 Antibody (Catalog # A06612) . Tested in ELISA, WB, IF applications. This antibody reacts with Human, Mouse, Rat.

Specifications

Catalog number

A06612

Size / count

0.1 mg

Dry ice

No

Hazardous

No

Discontinued

No

Background

CDCA8 is a component of a chromosomal passenger complex (CPC) required for stability of the bipolar mitotic spindle. The chromosomal passenger complex, which includes Survivin, CDCA8, INCENP and Aurora-B, is known to play crucial roles during mitosis and cell division. It was found that CDCA8 interacting with Aurora-B, INCENP and Survivin, increases during G2/M phase and then reduces after exit from M phase. CDCA8 is cell cycle regulated, down-regulated in response to p53/Rb-signaling, and up-regulated in many types of cancerous tissues. In Drosophila cells, inactivation of CDCA8 results in polyploidy, delayed mitosis and abnormal tissue development, indicating its critical role for cell proliferation. Recent studies show that CDCA8 is essential for cell proliferation during early embryonic development, and its early embryonic lethality cannot be rescued by the loss of p53. Its aberrant expression is linked to a poor prognosis for gastric cancer.

Synonyms

BOR, DasraB, MESRGP, BOREALIN, PESCRG3, Borealin, Cell division cycle-associated protein 8, hDasra-B

Gene Name

CDCA8

UniProt

Q53HL2

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

CDCA8 antibody was raised against a 19 amino acid synthetic peptide near the amino terminus of the human CDCA8. The immunogen is located within the first 50 amino acids of CDCA8.

Clonality

Polyclonal

Tissue Specificity

Highly expressed in spleen and lymph nodes (at protein level) .

Applications

ELISA, WB, IF

Field of Research

Stem Cells

Purification

CDCA8 Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Major effector of the TTK kinase in the control of attachment- error-correction and chromosome alignment.

Storage Conditions

CDCA8 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Observed Molecular Weight

31323 MW

Gene Name Synonym

Cell division cycle associated 8

Subcellular Location

Nucleus, nucleolus

Protein Name

Cell division cycle associated 8

Isotype

IgG

Contents

CDCA8 Antibody is supplied in PBS containing 0.02% sodium azide.