Anti-Splicing factor 3B subunit 2 SF3B2 Antibody

About this product

Boster Bio Anti-Splicing factor 3B subunit 2 SF3B2 Antibody catalog # A07047. Tested in WB, IHC, ICC/IF applications. This antibody reacts with Human, Mouse, Rat.

Specifications

Catalog number

A07047

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

Splicing factor 3B subunit 2; Pre-mRNA-splicing factor SF3b 145 kDa subunit; SF3b145; Spliceosome-associated protein 145; SAP 145; SF3B2; SAP145

Gene Name

SF3B2

UniProt

Q13435

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant fusion protein of human SF3B2 (NP_006833.2) .

Clonality

Polyclonal

Applications

WB, IHC, ICC, IF

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Concentration

1 mg/mL

Form

Liquid

Function

Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex (PubMed:27720643) . SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937) . May also be involved in the assembly of the 'E' complex (PubMed:10882114) . Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron (PubMed:15146077) .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

100228 MW

Gene Name Synonym

Splicing factor 3B subunit 2

Subcellular Location

Nucleus

Protein Name

Splicing factor 3B subunit 2

Contents

Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2